Stavroula Hatzios, Ph.D., is an Assistant Professor in the Department of Molecular, Cellular and Developmental Biology and a member of the Microbial Sciences Institute at Yale University. She received her B.S. in Chemistry from the Massachusetts Institute of Technology and her Ph.D. in Chemistry from the University of California, Berkeley. As a graduate student with Carolyn Bertozzi, she identified an osmotic stress response pathway that modulates the cell wall structure and antibiotic resistance of the tuberculosis pathogen Mycobacterium tuberculosis. After earning her Ph.D., she was awarded a global health research fellowship to study the population genetics of M. tuberculosis in Uganda. She completed her postdoctoral work in Matthew Waldor’s laboratory at Harvard Medical School and Brigham and Women’s Hospital, where she was a Charles A. King Trust Postdoctoral Fellow. There, she used activity-based proteomics to study the enzymatic crosstalk between bacterial and host cells in an animal model of cholera. In January 2017, Stavroula joined the faculty of Yale University as an Assistant Professor in the Department of Molecular, Cellular and Developmental Biology. Her laboratory studies enzymes and other proteins that shape host-microbe dynamics in gastrointestinal infections.
My laboratory uses a broad range of chemical and biological tools to explore the functional proteome of bacterial infections. We are interested in understanding what bacterial and host proteins are active during infection, how they impact molecular interactions between pathogen and host, and how infection-associated environmental cues influence protein function at the host-microbe interface. We are addressing these questions using the bacterial pathogens Helicobacter pylori and Vibrio cholerae in order to uncover biochemical pathways that shape severe gastrointestinal diseases including gastric cancer and cholera.