Sudheesh Allikka Parambil (van Wolfswinkel Lab) Published a New Paper in Nucleic Acids Research

photo of sudheesh alliika parambil
January 22, 2024

Our study explores how stem cells maintain their transcriptome integrity. We found that, in planarians, the PIWI protein called SMEDWI-1, associates with monosomes (ribosomal units) during pioneer round of translation, to help process the poorly translated (ex: structural) RNAs into small non-coding RNAs called piRNAs. This process helps filter out dysfunctional transcripts from entering the translational machinery, ensuring the health of stem cells. 

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