Pyle Lab Studies the RNA Genome of SARS-CoV-2 and is Discovering New Tools for Combating Pandemics in the Future

The Pyle Laboratory has committed the last nine months to determining the structural features within the RNA genome of SARS-CoV-2 (in virus infected cells), and through these efforts have made important discoveries about the attributes and vulnerabilities of the virus while developing new tools for combating pandemics in the future.  The work, which was a feat of biochemistry and high-biosafety level cell biology,  is now being published in a series of three papers in Molecular Cell (where the detailed RNA structures within the viral genome are presented), the Journal of Virology (where it was spotlighted as paper of the month) and a third paper that is available in BioRXiv. 

This work represents the tireless efforts of four intrepid graduate students in MCDB (Han Wan), MB&B (Nick Huston), Chemistry (Rafael Tavares), and Immunobiology/Lab Medicine (Madeline Strine).  

Visit Molecular Cell to view  “Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms.

Visit J. Virology to view “The global and local distribution of RNA structure Throughout the SARS-CoV-2 genome.” 

Visit BioRXiv to view “Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium”.