Jacobs-Wagner Lab: A bacterial remnant may explain arthritis in Lyme patients

Even after antibiotic treatment, some Lyme disease patients continue to suffer from debilitating arthritis. A new Yale study may explain why.

This study — led by the lab of Christine Jacobs-Wagner, the William H. Fleming, M.D. Professor of Molecular, Cellular, and Developmental Biology and professor of microbial pathogenesis — found peptidoglycan, a major component of bacterial cell walls, in the joint fluid of patients who had received intensive antibiotic treatment for Lyme arthritis. Also, in a mouse model, the Borrelia peptidoglycan was found to cause joint inflammation.

For the full story, visit: https://news.yale.edu/2019/06/21/bacterial-remnant-may-explain-arthritis-lyme-patients