Iwasaki & Pyle Labs: Drug shows promise as immune therapy for cancer
October 14, 2019
A therapy developed by Yale researchers stimulates immune cells to shrink or kill tumors in mice, according to a new study published in the Journal of Experimental Medicine. The therapy is effective alone or in combination with existing cancer immunotherapies, and it appears to have lasting effects, the researchers said.
The research team, led by Yale investigators Akiko Iwasaki and Anna Pyle, examined whether a synthetic RNA molecule developed to fight viruses could also trigger an immune response against tumors. The molecule, called Stem Loop RNA 14 (SLR14), was specifically designed to activate a gene that detects viruses and other threats in cells.