Binyam Mogessie Lab published in Science Advances

binyam mogessie with research image
January 30, 2023

Female reproductive aging is accompanied by high incidence of aneuploidy in eggs. Despite decades of investigation, the molecular origins of age-related egg aneuploidy remain a mystery. In a newly published paper, the Mogessie lab shows that spindle actin, a machinery that is unique to reproductive cells, prevents chromosomal abnormalities in eggs of reproductively older females. Using advanced microscopy and rapid protein degradation technologies, they have found that age-dependent loss of spindle actin apparatus predisposes mammalian eggs to aneuploidies that are broadly associated with miscarriages, infertility and birth-related genetic disorders. This discovery provides new insights into cellular architectures that underpin female reproductive longevity.

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