Yale Science Building, Room 116
Research
Our lab studies organelle structure and dynamics. In particular, we aim to understand how the nucleus establishes and maintains its unique structure during dynamic cellular processes such as cell division and embryonic development. We focus on the nuclear envelope, a specialized membrane that surrounds and protects the genome. Genes that encode nuclear envelope associated proteins are often found mutated in human genetic disorders called envelopathies. To dissect the critical role of the nuclear envelope and nuclear envelope associated proteins in nuclear dynamics we use high-resolution quantitative fluorescence time-lapse microscopy and genetic tools available in C. elegans and mammalian cells.