Schepartz Lab in the news: Yale scientists open up new world for biologics — inside the cell.
January 4, 2019
Schepartz and colleagues here at Yale now report the identity of a molecular key that effectively unlocks the endosome, allowing the selective passage into the cell interior of potentially life-saving protein drugs. This discovery was reported in the journal Proceedings of the National Academy of Science, USA.
Schepartz — working with graduate students Angela Steinauer, Jonathan LaRochelle, and Susan Knox, postdoctoral associate Rebecca Wissner, and undergraduate Samuel Berry — reports that the endosome unlocking key is the homotypic fusion and vacuole protein sorting (HOPS) complex — a multi-protein assembly that tethers certain endosomes together to allow them to fuse. When the HOPS complex is functional, protein therapeutics escape from endosomes. When it is not functional, they remain trapped within.