Anna Pyle’s lab is Attacking RNA with Small-Molecule Drugs.
October 24, 2018
Yale researchers have developed a way to target RNA with small-molecule drugs, creating a new method for tapping into a vast number of biological mechanisms critical to metabolism and gene expression.
Pyle’s team identified small molecules that would inhibit a particular group of large, self-splicing ribozymes found in bacteria, plants, and fungi — but not found in mammals. These RNA molecules have an elaborate structure that contains tiny, solvent-accessible pockets for a small molecule drug to bind with the larger molecule.