December 2020

Happy Holidays MCDB!

While in hindsight, 2020 was a challenging year, we have gotten through it. I am so thankful to be part of this community—a community that has pulled together with cheer and resilience. And, despite the difficulties, setbacks and stresses, we have still managed to carry on and present some great science. Here’s a snapshot of a few notable MCDB research publications from 2020 for your enjoyment.

To all of our members, please take some time over the winter break to rest and rejuvenate—and to look forward to 2021!
With all best wishes, Vivian

Highlights of research advances from 2020 (one per lab; first and last authors from MCDB):

Chromatin regulatory genes differentially interact in networks to facilitate distinct GAL1 activity and noise profiles. Moreno DF, Acar M. Curr Genet. 2020

Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. Penfield L, Shankar R, Szentgyörgyi E, Laffitte A, Mauro MS, Audhya A, Müller-Reichert T, Bahmanyar S. J Cell Biol. 2020

A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation.Yu D, Breaker RR. RNA. 2020
Molecular Logic and Evolution of Bitter Taste in Drosophila. Dweck HKM, Carlson JR. Curr Biol. 2020

Mechanism for analogous illusory motion perception in flies and humans. Agrochao M, Tanaka R, Salazar-Gatzimas E, Clark DA. Proc Natl Acad Sci U S A. 2020

Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.  Jaime-Figueroa S, Buhimschi AD, Toure M, Hines J, Crews CM. Bioorg Med Chem Lett. 2020

Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters. Demir M, Kadakia N, Anderson HD, Clark DA, Emonet T. Elife. 2020

A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis. Feke AM, Hong J, Liu W, Gendron JM. Genetics. 2020

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Shook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V. Cell Stem Cell. 2020

Reprogramming of Stem Cell Activity to Convert Thorns into Branches.  Zhang F, Rossignol P, Huang T, Wang Y, May A, Dupont C, Orbovic V, Irish VF. Curr Biol. 2020

Cryo-electron microscopy structures of pyrene-labeled ADP-Pi- and ADP-actin filaments. Chou SZ, Pollard TD. Nat Commun. 2020

Sequencing and Structure Probing of Long RNAs Using MarathonRT: A Next-Generation Reverse Transcriptase.Guo LT, Adams RL, Wan H, Huston NC, Potapova O, Olson S, Gallardo CM, Graveley BR, Torbett BE, Pyle AM. J Mol Biol. 2020

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